ABSTRACT
Objective To investigate the effect of the family nursing intervention on treatment of children with asthma, and explore the effect of family nursing intervention on the pulmonary function and quality of life in asthmatic children. Methods A total of 260 children with asthma were recruited at the First Affiliated Hospital of Xi'an Jiaotong University from July 2012 to July 2015. They were randomly divided into observation and control groups with 130 cases in each group. The control group were given routine nursing and regular treatment, and the observation group were received additional family nursing intervention management at the same time. We use Pediatric Asthma Quality of Life Questionnaire (PAQLQ) and pulmonary function testing to evaluate the influence of family nursing intervention on treatment effect and quality of life of asthmatic children. Results The total effective rate was 93% in the observation group and was 65% in the control group (P＜0.05) . The pulmonary function and quality of life were significant higher in the intervention group compared with the control group after intervention. Parents’satisfaction was significantly higher in the intervention group (P＜0.05) . Conclusion Family nursing intervention is an effective mode of management of children with asthma that can obviously improve pulmonary function and quality of life of asthmatic children. Moreover, family nursing intervention also contributes to raising parents'satisfaction.
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of hemoperfusion treatment on serum interleukin-17 (IL-17) and IL-23 levels in children with Henoch-Schönlein purpura (HSP).</p><p><b>METHODS</b>Eighty-seven children who were diagnosed with HSP and who had received hemoperfusion treatment between January 2011 and December 2012 were enrolled. Twenty-seven sex- and age-matched healthy children were recruited as normal controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of IL-17 and IL-23.</p><p><b>RESULTS</b>The serum IL-23 and IL-17 levels in the HSP group were significantly higher than in the control group (P<0.05). After hemoperfusion treatment, the serum IL-23 and IL-17 levels in the HSP group were significantly reduced to the levels of the control group. Serum serum IL-17 level was positively correlated with serum IL-23 level (P<0.05) in children with HSP.</p><p><b>CONCLUSIONS</b>Hemoperfusion treatment can reduce serum IL-23 and IL-17 levels in children with HSP, suggesting that the treatment may be effective for HSP.</p>
Subject(s)
Child , Child, Preschool , Female , Humans , Male , Hemoperfusion , Interleukin-17 , Blood , Physiology , Interleukin-23 , Blood , Physiology , IgA Vasculitis , Allergy and Immunology , TherapeuticsABSTRACT
<p><b>OBJECTIVE</b>To explore the method for early diagnosis and pathogenesis of MYH9-related syndrome through analysis of the clinical manifestation and gene mutation of a Chinese family with MYH9-related syndrome.</p><p><b>METHODS</b>Peripheral blood samples were collected from a three-generation Chinese family with MYH9-related syndrome (11 individuals, including 3 patients) and 100 healthy individuals. Polymerase chain reaction (PCR) amplification and direct sequencing of DNA were performed to analyze mutations of MYH9 gene.</p><p><b>RESULTS</b>Thrombocytopenia, increased volume of platelet, and granulocyte inclusion bodies were found in the patients with MYH9-related syndrome via a peripheral blood test. A missense mutation of a base pair (G-A) in exon 30 was revealed by PCR amplification and direct sequencing of MYH9 of the proband. That lead to Asp-Asn substitution at position 1424 (D1424N mutation). The mutation was the same as in other patients with MYH9-related syndrome. It was not found in healthy people from the Chinese family or in the other 100 healthy individuals.</p><p><b>CONCLUSIONS</b>Patients with MYH9-related syndrome show diverse symptoms. Mutation of MYH9 gene may be the molecular mechanism of MYH9-related syndrome, and D1424N mutation of MYH9 has not been reported in Chinese people. Early diagnosis of MYH9-related syndrome can be carried out by investigating family history and making early examinations.</p>